A Variance-Component Framework for Pedigree Analysis of Continuous and Categorical Outcomes
نویسندگان
چکیده
منابع مشابه
A Variance-Component Framework for Pedigree Analysis of Continuous and Categorical Outcomes.
Variance-component methods are popular and flexible analytic tools for elucidating the genetic mechanisms of complex quantitative traits from pedigree data. However, variance-component methods typically assume that the trait of interest follows a multivariate normal distribution within a pedigree. Studies have shown that violation of this normality assumption can lead to biased parameter estima...
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ژورنال
عنوان ژورنال: Statistics in Biosciences
سال: 2009
ISSN: 1867-1764,1867-1772
DOI: 10.1007/s12561-009-9010-5